Musi waChivabvu 1, timu yekutsvagisa yeSchool of Pharmacy yeSun Yat-Sen University yakaburitsa chinyorwa chewongororo chakanzi “Kufambira mberi kweKutsvakurudza pamusoro peToxicity Mechanism.Midzanga yemagetsipaRespiratory System” mu “International Journal of Molecular Science”, ine mvumo SCI magazini mumunda wepasi rose molecular mushonga.Kukuvadza kwefodya yemagetsi kuhurongwa hwekufema kwevanhu kwakadzikira zvakanyanya pane yefodya yechinyakare.

mufananidzo

Mufananidzo: Chikwata chekutsvagisa cheSun Yat-sen University chakaburitswa muInternational Journal yeMolecular Science

Vatsvakurudzi vakaongorora uye vakapfupisa 108 mabhuku ane hukama akaburitswa kubva 2010 mumunda wemidzanga yemagetsinemidzanga yechinyakare, ndokuenzanisa misiyano iripomidzanga yemagetsiuye fodya yechinyakare kubva pamaonero ezvikamu zvikuru uye nzira dzehupfu.

Panyaya yezvikamu zvikuru, kubvirae-fodyawedzera nicotine uye cosolvents, uye haina fodya, zvikamu zvadzo zviri nyore kupfuura zvechinyakare fodya;mushure meatomization, zvinhu zvinokuvadza mu-e-cigarette aerosols zvakaderera pane izvo zvechinyakaremidzanga.

Kunyanya, zvese zviri zvivirimidzanga yemagetsiuye midzanga yechinyakare ine nicotine, asi zviri muchetura zvakaita sesimbi carbonyl compounds, nitrosamines, volatile organic compounds, uye polycyclic anonhuwirira hydrocarbons yakaderera zvikuru pane yefodya.

Panyaya ye toxicity mechanism, bepa rakaona kuti mhedzisiro yee-fodyapamatishu makuru uye nhengo dzemuviri uye intracellular signaling nzira dzakafanana nedzefodya;zvisinei, nhamba huru yezvidzidzo zvakaratidza kuti zvichienzaniswa nefodya, chiyero chekukuvadza kunokonzerwa nee-fodyayakaderera.

Iri bepa rakaita ongororo yakazara yesainzi yefodya yemagetsi nefodya yechinyakare, uye yakagumisa kuti kunyangwemidzanga yemagetsihaina kukuvadza zvachose, haina kukuvadza zvakanyanya pane yefodya yechinyakare, uye inogona kuve inoderedza kukuvadza inotsiva yekudzikisa njodzi yezvirwere zvine chekuita nekuputa.

Pamusoro pezvo, bepa rinosimbisawo kuti zvinodikanwa kuti uwedzere kudzidza maitiro ee-fodyapavashandisi vefodya yechinyakare, unganidza data rakawanda kuti uwane ruzivo rwehumbowo hunobva pahumbowo, uye batsira vanhu kuonae-fodyazvine mufungo uye zvine musoro pasina kufuratira njodzi dzinogona kuitika.

Liu Peiqing, mumwe wevanyori vanowirirana vebepa, purofesa weChikoro cheFarmacy cheSun Yat-sen University uye director weNational and Local Joint Engineering Laboratory for the Evaluation and Evaluation of New Drugs, akati bepa iri rinogona kupa zvesainzi. chirevo chekuti veruzhinji vave nekunzwisisa kwakadzama kwee-fodya, uye zvakare inotsigira kugadzwa kwechigadzirwa chemhando zviyero uye zviyero.Toxicity evaluation system, kukosha kwekumisikidza ingredient yemukati.

Panguva imwecheteyo, timu yekutsvagisa inotendawo kuti kutsvagisa kwesainzi kunodiwa kuti uwane ruzivo-rwakavakirwa ruzivo kuti uongorore zvakadzama kuchengetedzwa kwenguva refu kwe.e-fodya.

Kubata: Judy Iye

Email: judy@intl6.aierbaita.com

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